Vimovo and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vimovo (esomeprazole magnesium; naproxen) and Ultram (tramadol hydrochloride). Common drug interactions include arrhythmia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Vimovo and Ultram. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 11, 2026

23 people who take Vimovo and Ultram together, and have interactions are studied.

What are the common drug interactions of Vimovo and Ultram, by gender? *:

female:

Arrhythmia (irregular heartbeat)
Carotid artery stenosis (narrowing of carotid artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough
Drug hypersensitivity
Dyspepsia (indigestion)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Heart rate increased
Hypertension (high blood pressure)

male:

Renal failure (kidney dysfunction)
Oesophagitis (inflammation of oesophagus)

What are the common drug interactions of Vimovo and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug effect increased
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Headache (pain in head)
Heart rate increased
Hypertension (high blood pressure)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mitral valve incompetence (inefficient heart valve)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Non-cardiac chest pain
Oropharyngeal pain
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 26.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 21.74%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 13.04%
High Blood Pressure: 3 people, 13.04%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 8.70%
Indigestion: 2 people, 8.70%
Hypersensitivity: 2 people, 8.70%
High Blood Cholesterol: 2 people, 8.70%
Erosive Oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time): 2 people, 8.70%
Asthma: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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