Vimpat and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vimpat (lacosamide) and Paxil (paroxetine hydrochloride). Common drug interactions include osteomyelitis among females and atrioventricular block among males.

The phase IV clinical study analyzes what interactions people have when they take Vimpat and Paxil. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,832 Vimpat users. Check the latest studies of Vimpat.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

On Aug, 04, 2026

50 people who take Vimpat and Paxil together, and have interactions are studied.

What are the common drug interactions of Vimpat and Paxil, by gender? *:

female:

Osteomyelitis (infection of bone)
Performance status decreased
Petit mal epilepsy (absence seizure)
Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Stomatitis (inflammation of mucous membrane of mouth)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Weight decreased
Fall
Vision blurred

male:

Atrioventricular block (heart block)
Chest pain
Staphylococcal infection (an infection with staphylococcus bacteria)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Blood sodium decreased
Chorioretinopathy (collection of fluid under the retina that results in visual distortion)
Cystic fibrosis (disease of the secretary glands)
Decreased appetite

What are the common drug interactions of Vimpat and Paxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Diplopia (double vision)
Feeling guilty
Headache (pain in head)
Heart rate irregular
Intentional self-injury
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Vision blurred

20-29:

Abdominal discomfort
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Nausea (feeling of having an urge to vomit)
Stomatitis (inflammation of mucous membrane of mouth)
Weight decreased

30-39:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Dehydration (dryness resulting from the removal of water)
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Decreased appetite
Drug dependence
Infrequent bowel movements
Nausea (feeling of having an urge to vomit)
Suicidal ideation

40-49:

Hospitalisation
Vision blurred

50-59:

Fall
Asthenia (weakness)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diplopia (double vision)
Dysarthria (speech disorder)
Facial bones fracture (bone fracture of face)
Fatigue (feeling of tiredness)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Contusion (a type of hematoma of tissue in which capillaries)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Oedema peripheral (superficial swelling)
Performance status decreased
Vision blurred
Weight increased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fall

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 28.00%
Stress And Anxiety: 7 people, 14.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 10.00%
Headache (pain in head): 5 people, 10.00%
High Blood Pressure: 4 people, 8.00%
Sleep Disorder: 4 people, 8.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.00%
Constipation: 4 people, 8.00%
Diabetes: 3 people, 6.00%
Blood Glucose Abnormal: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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