Vioxx and Activella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vioxx (rofecoxib) and Activella (estradiol; norethindrone acetate). Common drug interactions include breast cancer among females.

The phase IV clinical study analyzes what interactions people have when they take Vioxx and Activella. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

On Jul, 05, 2026

29 people who take Vioxx and Activella together, and have interactions are studied.

What are the common drug interactions of Vioxx and Activella, by gender? *:

female:

Breast cancer
Pulmonary embolism (blockage of the main artery of the lung)
General physical health deterioration (weak health status)
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Abdominal pain upper
Anxiety
Arthralgia (joint pain)
Blood cholesterol increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

n/a

What are the common drug interactions of Vioxx and Activella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

50-59:

Pulmonary embolism (blockage of the main artery of the lung)
Breast cancer
Fall
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Head injury
Hypertension (high blood pressure)
Cardiac failure congestive
General physical health deterioration (weak health status)
Blood cholesterol increased
Dysarthria (speech disorder)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Breast cancer
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Electrocardiogram t wave inversion
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Joint injury
Lacunar infarction (a type of stroke)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)

What are the existing conditions these people have? *

Menopausal Symptoms: 7 people, 24.14%
Pain: 5 people, 17.24%
Joint Pain: 5 people, 17.24%
Ill-Defined Disorder: 3 people, 10.34%
Vaginal Bleeding: 2 people, 6.90%
Postmenopausal Haemorrhage (post-menopausal bleeding): 2 people, 6.90%
Hormone Level Abnormal: 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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