Vioxx and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vioxx (rofecoxib) and Azelastine (azelastine hydrochloride). Common drug interactions include chronic kidney disease among females and cor pulmonale chronic among males.

The phase IV clinical study analyzes what interactions people have when they take Vioxx and Azelastine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,399 Azelastine users. Check the latest studies of Azelastine.

On Jul, 10, 2026

11 people who take Vioxx and Azelastine together, and have interactions are studied.

What are the common drug interactions of Vioxx and Azelastine, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Drug hypersensitivity
Oral pain
Abdominal abscess (collection of pus in abdomen)
Abscess (pus)
Ankle fracture
Arthralgia (joint pain)
Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)

male:

Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Cough
Renal failure chronic (long lasting kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Rosacea (a skin condition that causes facial redness)
Signet-ring cell carcinoma (signet cell cancer tumour)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Testicular failure (testicles cannot produce sperm or male hormones)
Fatigue (feeling of tiredness)
Gastric cancer (stomach cancer)

What are the common drug interactions of Vioxx and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
Papillary thyroid cancer

50-59:

Abdominal abscess (collection of pus in abdomen)
Abscess (pus)
Ankle fracture
Arthralgia (joint pain)
Bone disorder
Cellulitis (infection under the skin)
Chondropathy (disease of the cartilage)
Device failure
Gastric cancer (stomach cancer)
Gastric cancer stage iii (the tumour has invaded nearby organs, such as the liver, colon, or spleen. cancer cells have not spread to lymph nodes or to distant organs)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Oral pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal failure chronic (long lasting kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Rosacea (a skin condition that causes facial redness)

What are the existing conditions these people have? *

Pain: 4 people, 36.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 36.36%
Infection: 3 people, 27.27%
Hypokalemia (low potassium): 3 people, 27.27%
Arrhythmias (irregular heartbeat): 3 people, 27.27%
Asthma: 3 people, 27.27%
Cough: 3 people, 27.27%
Depression: 3 people, 27.27%
Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 27.27%
High Blood Pressure: 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Vioxx and Azelastine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously