Vistaril and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include embolism arterial among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Yaz. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

On Jul, 12, 2026

53 people who take Vistaril and Yaz together, and have interactions are studied.

What are the common drug interactions of Vistaril and Yaz, by gender? *:

female:

Embolism arterial (blood clot that has travelled through your arteries and become stuck)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gallbladder polyp (growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Jugular vein thrombosis (clot in jugular vein)
Left ventricular dysfunction
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Multiple fractures
Nervousness
Osteoporosis (bones weak and more likely to break)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Cholecystitis chronic (long lasting infection of gallbladder)
Circulatory collapse
Haematoma (collection of blood outside the blood vessels)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Ischaemic ulcer (arterial ulcer)
Multi-organ failure (multisystem organ failure)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)

What are the common drug interactions of Vistaril and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
General physical health deterioration (weak health status)
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Migraine (headache)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Abdominal pain upper
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain

20-29:

Biliary colic
Pancreatitis (inflammation of pancreas)
Abdominal pain
Blood disorder
Depression
Depression suicidal (suicide depressive disorder)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspepsia (indigestion)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gallbladder polyp (growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder)

30-39:

Pulmonary embolism (blockage of the main artery of the lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Chest pain
Dyspnoea (difficult or laboured respiration)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Coagulopathy (blood's ability to clot is impaired)
Headache (pain in head)
Pain
Pain in extremity
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Emotional distress
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Abdominal pain upper
Biliary colic
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

50-59:

Chest pain
Dysmenorrhoea (painful menstruation)
Dyspnoea (difficult or laboured respiration)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Interstitial lung disease
Cardiac valve disease (heart valve disease)
Diastolic dysfunction
Dysgraphia (impaired ability to learn to write)

60+:

Alopecia (absence of hair from areas of the body)
Arrhythmia (irregular heartbeat)
Haematoma (collection of blood outside the blood vessels)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Ischaemic ulcer (arterial ulcer)
Multi-organ failure (multisystem organ failure)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)
Onychomadesis (a periodic idiopathic shedding of the nails)
Peripheral ischaemia (impaired circulation to an extremity)

What are the existing conditions these people have? *

Premenstrual Syndrome: 12 people, 22.64%
Pain: 12 people, 22.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 11.32%
Migraine (headache): 6 people, 11.32%
Depression: 5 people, 9.43%
Nausea (feeling of having an urge to vomit): 4 people, 7.55%
Menstruation Irregular: 4 people, 7.55%
Acne (skin problems that cause pimples): 4 people, 7.55%
Sleep Disorder: 3 people, 5.66%
Multiple Allergies (allergy to multiple agents): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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