Vitamin b12 and Feldene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin b12 (cobalamin) and Feldene (piroxicam). Common drug interactions include balance disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin b12 and Feldene. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,681 Vitamin b12 users. Check the latest studies of Vitamin b12.

What is Feldene?

Feldene has active ingredients of piroxicam. It is often used in arthritis. eHealthMe is studying from 3,913 Feldene users. Check the latest studies of Feldene.



On Jul, 26, 2026

21 people who take Vitamin b12 and Feldene together, and have interactions are studied.

Vitamin b12 and Feldene drug interactions.

What are the common drug interactions of Vitamin B12 and Feldene, by gender? *:

female:

  1. Balance disorder
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  4. Ataxia (loss of full control of bodily movements)
  5. Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
  6. Cerebral atrophy (decrement in size of brain)
  7. Cerebral infarction (less blood supply to brain resulting tissue damage)
  8. Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
  9. Confusional state
  10. Dysarthria (speech disorder)

male:

  1. Chronic kidney disease
  2. Death
  3. Hypertension (high blood pressure)
  4. Hypophagia (reduced food intake)
  5. Migraine (headache)
  6. Nephrogenic anaemia (anaemia due to kidney disease)
  7. Renal failure (kidney dysfunction)
  8. Renal injury (kidney injury)
  9. Respiratory failure (inadequate gas exchange by the respiratory system)
  10. Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Vitamin B12 and Feldene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Depression
  2. Depression suicidal (suicide depressive disorder)
  3. Diarrhoea
  4. Hypersomnia (excessive daytime sleepiness (eds))
  5. Hypophagia (reduced food intake)
  6. Injection site pain
  7. Migraine (headache)
  8. Somnolence (a state of near-sleep, a strong desire for sleep)
  9. Suicidal ideation

50-59:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Ataxia (loss of full control of bodily movements)
  3. Balance disorder
  4. Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
  5. Cerebral atrophy (decrement in size of brain)
  6. Cerebral infarction (less blood supply to brain resulting tissue damage)
  7. Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
  8. Confusional state
  9. Dysarthria (speech disorder)
  10. Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)

60+:

  1. Death
  2. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  3. Fall
  4. Haematocrit decreased
  5. Haemoglobin decreased
  6. Hip arthroplasty
  7. Hospitalisation
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Infection
  10. Joint range of motion decreased (disease of joint movement)

What are the existing conditions these people have? *

  1. Pain: 9 people, 42.86%
  2. Depression: 6 people, 28.57%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 28.57%
  4. Headache (pain in head): 6 people, 28.57%
  5. Joint Pain: 5 people, 23.81%
  6. Migraine (headache): 4 people, 19.05%
  7. Upper Respiratory Tract Infection: 3 people, 14.29%
  8. High Blood Pressure: 3 people, 14.29%
  9. Aneurysm (enlargement of an artery caused by a weakening of the artery wall): 3 people, 14.29%
  10. Asthma: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vitamin b12 and Feldene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamin b12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Feldene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin b12 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Feldene and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on cobalamin and piroxicam (the active ingredients of Vitamin b12 and Feldene, respectively), and Vitamin b12 and Feldene (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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