Vitamin e and Efudex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin e (tocopherols and tocotrienols) and Efudex (fluorouracil). Common drug interactions include bacteraemia among females and activated partial thromboplastin time shortened among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin e and Efudex. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

On Jul, 12, 2026

13 people who take Vitamin e and Efudex together, and have interactions are studied.

What are the common drug interactions of Vitamin E and Efudex, by gender? *:

female:

Bacteraemia (presence of bacteria in the blood)
Chest discomfort
Chest pain
Cough
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Dyspnoea exertional (breathlessness or shortness of breath)
Neoplasm (tumour)
Postoperative wound infection

male:

Activated partial thromboplastin time shortened
Anaemia (lack of blood)
Hypokalaemia (low potassium)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased
Urinary tract infection
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Vitamin E and Efudex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Activated partial thromboplastin time shortened
Anaemia (lack of blood)
Hypokalaemia (low potassium)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased
Urinary tract infection
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 23.08%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 3 people, 23.08%
Skin Papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections): 3 people, 23.08%
Hypotension (abnormally low blood pressure): 3 people, 23.08%
Skin Cancer: 3 people, 23.08%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 23.08%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 23.08%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
Hypovolaemia (a decreased volume of circulating blood in the body): 3 people, 23.08%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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