Vitamin e and Periogard drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin e (tocopherols and tocotrienols) and Periogard (chlorhexidine gluconate). Common drug interactions include pain among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin e and Periogard. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

What is Periogard?

Periogard has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 3,814 Periogard users. Check the latest studies of Periogard.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

100 people who take Vitamin e and Periogard together, and have interactions are studied.

Vitamin e and Periogard drug interactions.

What are the common drug interactions of Vitamin E and Periogard, by gender? *:

female:

Pain
Peripheral swelling
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Rash
Asthenia (weakness)
Back pain
Body temperature increased
Diarrhoea
Ear pain

male:

Thrombocytopenia (decrease of platelets in blood)
Actinic keratosis (skin disease due to sun exposure)
Calcinosis (calcium deposits in any soft tissue)
Cardiac arrest
Carotid artery stenosis (narrowing of carotid artery)
Cellulitis (infection under the skin)
Cerebral atrophy (decrement in size of brain)
Cervical cyst (mucus-filled cyst on the surface of the cervix)
Chest wall abscess
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the common drug interactions of Vitamin E and Periogard, by age (0-1 to 60+)? *:

0-1:

Thrombocytopenia (decrease of platelets in blood)

2-9:

n/a

10-19:

Carotid artery stenosis (narrowing of carotid artery)
Cellulitis (infection under the skin)
Cerebral atrophy (decrement in size of brain)
Cervical cyst (mucus-filled cyst on the surface of the cervix)
Chest wall abscess
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Compression fracture (fracture due to pressure caused by injury)
Contusion (a type of hematoma of tissue in which capillaries)
Deafness

20-29:

n/a

30-39:

n/a

40-49:

Joint swelling
Sinusitis (inflammation of sinus)
Body temperature increased
Diarrhoea
Ear pain
Headache (pain in head)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Night sweats (sweating in night)
Abdominal pain upper
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 97 people, 97.00%
Diarrhea: 17 people, 17.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 16 people, 16.00%
Psoriasis (immune-mediated disease that affects the skin): 16 people, 16.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 16 people, 16.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 16 people, 16.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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