Vivactil and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivactil (protriptyline hydrochloride) and Aleve (naproxen sodium). Common drug interactions include constipation among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Vivactil and Aleve. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 08, 2026

54 people who take Vivactil and Aleve together, and have interactions are studied.

What are the common drug interactions of Vivactil and Aleve, by gender? *:

female:

Constipation
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Road traffic accident
Weight decreased
Weight increased
Pain in extremity
Alopecia (absence of hair from areas of the body)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Pneumonia
Back disorder
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Suicidal ideation
Blood cholesterol increased
Depression
Drug ineffective
Insomnia (sleeplessness)
Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Vivactil and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Hypertension (high blood pressure)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Drug hypersensitivity
Tendon rupture (tear of tendon)
Depression
Suicidal ideation

40-49:

n/a

50-59:

n/a

60+:

Hypersensitivity
Laryngitis (inflammation of the larynx)
Osteopenia (a condition where bone mineral density is lower than normal)
Peripheral swelling
Sedation
Thrombosis (formation of a blood clot inside a blood vessel)
Viral upper respiratory tract infection
Vitamin d deficiency
Vomiting
Loss of consciousness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 52 people, 96.30%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 39 people, 72.22%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 18.52%
High Blood Pressure: 7 people, 12.96%
Depression: 7 people, 12.96%
Drowsiness: 3 people, 5.56%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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