Vivactil and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivactil (protriptyline hydrochloride) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include alopecia among females and benign prostatic hyperplasia among males.

The phase IV clinical study analyzes what interactions people have when they take Vivactil and Vitamin e. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

On Jul, 13, 2026

31 people who take Vivactil and Vitamin e together, and have interactions are studied.

Vivactil and Vitamin e drug interactions.

What are the common drug interactions of Vivactil and Vitamin E, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Onychoclasis (breaking of the nails)
Pain in extremity
Intervertebral disc disorder (spinal disc disorder)
Hunger
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Anaemia (lack of blood)
Drug ineffective
Dyspepsia (indigestion)

male:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Insomnia (sleeplessness)
Prostate cancer

What are the common drug interactions of Vivactil and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Chest pain
Dyspnoea (difficult or laboured respiration)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Myalgia (muscle pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

n/a

60+:

Hypersensitivity
Laryngitis (inflammation of the larynx)
Peripheral swelling
Prostate cancer
Sedation
Thrombosis (formation of a blood clot inside a blood vessel)
Viral upper respiratory tract infection
Vitamin d deficiency
Vomiting
Anaemia (lack of blood)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 90.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 28 people, 90.32%
High Blood Pressure: 6 people, 19.35%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.90%
Depression: 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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