Vivactil and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivactil (protriptyline hydrochloride) and Zoloft (sertraline hydrochloride). Common drug interactions include blood pressure decreased among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Vivactil and Zoloft. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 28, 2026

18 people who take Vivactil and Zoloft together, and have interactions are studied.

What are the common drug interactions of Vivactil and Zoloft, by gender? *:

female:

Blood pressure decreased
Burning sensation
Dizziness
Fall
Headache (pain in head)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Pain
Pain in extremity

male:

Blood cholesterol increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Obesity (having too much body fat)
Weight decreased

What are the common drug interactions of Vivactil and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective

40-49:

Blood cholesterol increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Obesity (having too much body fat)
Weight decreased

50-59:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Drug hypersensitivity

60+:

Arthralgia (joint pain)
Pain in extremity
Drug hypersensitivity
Fall
Foot fracture
Pruritus (severe itching of the skin)
Wrist fracture
Blood cholesterol increased
Blood creatinine increased
Blood triglycerides increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 27.78%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Insomnia (sleeplessness): 2 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 11.11%
Compression Fracture (fracture due to pressure caused by injury): 2 people, 11.11%
Seasonal Allergy (allergic condition due to certain season): 1 person, 5.56%
Renal Disorder (kidney disease): 1 person, 5.56%
Pain: 1 person, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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