Vivelle-dot and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle-dot (estradiol) and Topamax (topiramate). Common drug interactions include cough among females and blood pressure decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle-dot and Topamax. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

On Jul, 11, 2026

69 people who take Vivelle-dot and Topamax together, and have interactions are studied.

Vivelle-dot and Topamax drug interactions.

What are the common drug interactions of Vivelle-Dot and Topamax, by gender? *:

female:

Cough
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Headache (pain in head)
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Back pain
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
General physical health deterioration (weak health status)
Insomnia (sleeplessness)

male:

Blood pressure decreased
Dizziness
Gait disturbance
Paralysis
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

What are the common drug interactions of Vivelle-Dot and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Adenomyosis (presence of ectopic glandular tissue found in muscle)
Contusion (a type of hematoma of tissue in which capillaries)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Oedema peripheral (superficial swelling)
Tenderness (pain or discomfort when an affected area is touched)

40-49:

Back pain
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression
Intervertebral disc protrusion (spinal disc protrusion)
Myalgia (muscle pain)

50-59:

Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Road traffic accident
Rotator cuff repair

60+:

Pain
Weight decreased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Joint injury
Lower limb fracture
Muscle spasms (muscle contraction)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 20.29%
Stress And Anxiety: 12 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 17.39%
Pain: 9 people, 13.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.14%
Sleep Disorder: 6 people, 8.70%
Nausea (feeling of having an urge to vomit): 5 people, 7.25%
Insomnia (sleeplessness): 5 people, 7.25%
Headache (pain in head): 5 people, 7.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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