Vivelle-dot and Zometa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle-dot (estradiol) and Zometa (zoledronic acid). Common drug interactions include pain among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle-dot and Zometa. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

On Jul, 06, 2026

35 people who take Vivelle-dot and Zometa together, and have interactions are studied.

Vivelle-dot and Zometa drug interactions.

What are the common drug interactions of Vivelle-Dot and Zometa, by gender? *:

female:

Pain
Abscess (pus)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Faecal incontinence (a lack of control over passing stool)
Injury
Lip and/or oral cavity cancer (cancer of lip or mouth)
Lip discolouration
Oedema peripheral (superficial swelling)
Osteopenia (a condition where bone mineral density is lower than normal)

male:

Chest pain
Depression
Cataract (clouding of the lens inside the eye)
Fatigue (feeling of tiredness)
Haematuria (presence of blood in urine)
Hypersomnia (excessive daytime sleepiness (eds))
Intervertebral disc degeneration (spinal disc degeneration)
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastases to bone (cancer spreads to bone)

What are the common drug interactions of Vivelle-Dot and Zometa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Accident
Affective disorder (mental disorder)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

40-49:

n/a

50-59:

Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply)
Retching (strong involuntary effort to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Gastritis (inflammation of stomach)
Wound infection staphylococcal
Atelectasis (partial or complete collapse of the lung)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Hydropneumothorax (presence of both air and fluid in the pleural space (lungs))

60+:

Fatigue (feeling of tiredness)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastases to bone (cancer spreads to bone)
Metastases to skin (cancer spreads to skin)
Osteoporosis (bones weak and more likely to break)
Pain
Renal impairment (severely reduced kidney function)
Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)

What are the existing conditions these people have? *

Bone Density Abnormal: 18 people, 51.43%
Osteoporosis (bones weak and more likely to break): 6 people, 17.14%

* Approximation only. Some reports may have incomplete information.

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