Vraylar and Fetzima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vraylar (cariprazine hydrochloride) and Fetzima (levomilnacipran hydrochloride). Common drug interactions include abscess oral among females and increased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Vraylar and Fetzima. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Vraylar?

Vraylar has active ingredients of cariprazine hydrochloride. eHealthMe is studying from 6,136 Vraylar users. Check the latest studies of Vraylar.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

On Jul, 18, 2026

21 people who take Vraylar and Fetzima together, and have interactions are studied.

What are the common drug interactions of Vraylar and Fetzima, by gender? *:

female:

Abscess oral (abscess in the mouth)
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Influenza
Influenza like illness
Infusion site swelling
Neuralgia (pain in one or more nerves)
Pain
Tooth disorder (tooth disease)
Upper respiratory tract infection

male:

Increased appetite
Multiple allergies (allergy to multiple agents)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Weight increased
Blood cholesterol increased
Blood glucose decreased
Blood pressure decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death
Decreased appetite

What are the common drug interactions of Vraylar and Fetzima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased

30-39:

Blood glucose decreased
Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Pain in jaw

40-49:

Abscess oral (abscess in the mouth)
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Influenza
Influenza like illness
Infusion site swelling
Neuralgia (pain in one or more nerves)
Pain
Tooth disorder (tooth disease)
Upper respiratory tract infection

50-59:

Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Drug ineffective
Constipation
Hyperhidrosis (abnormally increased sweating)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death

60+:

Decreased appetite
Increased appetite
Multiple allergies (allergy to multiple agents)
Weight increased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 23.81%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 19.05%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 4 people, 19.05%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 19.05%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 14.29%
Insomnia (sleeplessness): 3 people, 14.29%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 14.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 14.29%
Sleep Disorder: 2 people, 9.52%
Breast Cancer Female: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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