Vraylar and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vraylar (cariprazine hydrochloride) and Spironolactone (spironolactone). Common drug interactions include hospitalisation among females and urinary tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Vraylar and Spironolactone. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Vraylar?

Vraylar has active ingredients of cariprazine hydrochloride. eHealthMe is studying from 6,136 Vraylar users. Check the latest studies of Vraylar.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

45 people who take Vraylar and Spironolactone together, and have interactions are studied.

Vraylar and Spironolactone drug interactions.

What are the common drug interactions of Vraylar and Spironolactone, by gender? *:

female:

Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Hyperphagia (an abnormal appetite for food)
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Increased appetite
Insomnia (sleeplessness)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Liver injury

male:

Urinary tract infection
Diabetic foot
Blood glucose decreased
Decreased appetite
Depression
Dizziness
Drooling (drop saliva uncontrollably from the mouth)
Fall
Fatigue (feeling of tiredness)
Feeling hot

What are the common drug interactions of Vraylar and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cyst (a closed sac)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Mass
Muscle twitching
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal distension
Arthralgia (joint pain)
Cold sweat
Dehydration (dryness resulting from the removal of water)
Diarrhoea

30-39:

Migraine (headache)
Headache (pain in head)
Abdominal discomfort
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Food allergy
Fungal infection
Micturition urgency (urgency to pass the urine)
Myalgia (muscle pain)
Nightmare (unpleasant dream)

40-49:

Pain
Pyrexia (fever)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Blood glucose increased
Blood potassium decreased
Decreased appetite
Depression
Drooling (drop saliva uncontrollably from the mouth)
Fall
Increased appetite

50-59:

Urinary tract infection
Diabetic foot
Influenza
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Fatigue (feeling of tiredness)
Hospitalisation
Nonspecific reaction (unspecified reaction)
Abdominal distension
Abdominal pain
Alanine aminotransferase increased

60+:

Syncope (loss of consciousness with an inability to maintain postural tone)
Arthralgia (joint pain)
Peripheral swelling
Pruritus (severe itching of the skin)
White blood cell count decreased
Blood pressure decreased
Chills (felling of cold)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 15.56%
Cushing's Syndrome (obesity, a rounded face, increased fat): 7 people, 15.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 15.56%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 8.89%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 4 people, 8.89%
Drowsiness: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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