Vytorin and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vytorin (ezetimibe; simvastatin) and Nucynta (tapentadol hydrochloride). Common drug interactions include fall among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Vytorin and Nucynta. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 09, 2026

29 people who take Vytorin and Nucynta together, and have interactions are studied.

What are the common drug interactions of Vytorin and Nucynta, by gender? *:

female:

Fall
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Weight decreased
Blindness transient (sudden loss of vision)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Screaming (a long loud piercing cry)
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)
Vomiting
Aphasia (damage to the parts of the brain that control language)

male:

Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Decreased appetite
Diarrhoea
Disability
Dizziness
Dyspepsia (indigestion)

What are the common drug interactions of Vytorin and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Chest pain
Chronic kidney disease
Drug hypersensitivity
Headache (pain in head)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

50-59:

Fall
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Weight decreased
Blindness transient (sudden loss of vision)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Screaming (a long loud piercing cry)
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)
Vomiting
Aphasia (damage to the parts of the brain that control language)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cough
Decreased appetite
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dizziness
Dyspepsia (indigestion)
Erection increased
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Depression: 12 people, 41.38%
Stress And Anxiety: 11 people, 37.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 27.59%
Procedural Pain: 8 people, 27.59%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 7 people, 24.14%
Nausea (feeling of having an urge to vomit): 7 people, 24.14%
Diabetes: 6 people, 20.69%
High Blood Pressure: 6 people, 20.69%
Neuralgia (pain in one or more nerves): 4 people, 13.79%
Quit Smoking: 4 people, 13.79%

* Approximation only. Some reports may have incomplete information.

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