Vyvanse and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Estradiol (estradiol). Common drug interactions include insomnia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Estradiol. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,987 Estradiol users. Check the latest studies of Estradiol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

61 people who take Vyvanse and Estradiol together, and have interactions are studied.

Vyvanse and Estradiol drug interactions.

What are the common drug interactions of Vyvanse and Estradiol, by gender? *:

female:

Insomnia (sleeplessness)
Restless legs syndrome (a powerful urge to move your legs)
Ankle fracture
Breast cancer
Heart rate increased
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sinusitis (inflammation of sinus)
Sleep disorder

male:

Fatigue (feeling of tiredness)
Impaired healing

What are the common drug interactions of Vyvanse and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Haemorrhage (bleeding)
Pruritus (severe itching of the skin)

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Age-related macular degeneration
Anxiety
Colitis ulcerative (inflammation of colon with ulcer)
Retinal pigmentation (pigmentation of retina)
Impaired healing
Apathy
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood cholesterol increased

40-49:

Local swelling (swelling at the site of some application of substance or injury)
Muscle rupture (tear in muscle)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Neuroma (tumour of nerve tissue)
Neuropathy peripheral (surface nerve damage)
Nocturia (the need to get up in the night to urinate)
Oedema mouth (swelling of mouth)
Oral herpes (viral infection of mouth)
Pain

50-59:

Breast cancer
Sinusitis (inflammation of sinus)
Vertigo
Abdominal discomfort
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arthropathy
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cystitis interstitial (unknown cause characterized by bladder pain)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)

60+:

Pain
Constipation
Weight increased
Dehydration (dryness resulting from the removal of water)
Multi-vitamin deficiency (lack of vitamins)
Blood pressure increased
Hospitalisation
Knee arthroplasty
Dyspepsia (indigestion)
Headache (pain in head)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 36.07%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 27.87%
Drowsiness: 14 people, 22.95%
Depression: 8 people, 13.11%
Immunodeficiency Common Variable: 5 people, 8.20%
Stress And Anxiety: 4 people, 6.56%
High Blood Pressure: 4 people, 6.56%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 6.56%
Bipolar Disorder (mood disorder): 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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