Vyvanse and Olanzapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Olanzapine (olanzapine). Common drug interactions include depressed mood among females and cryptosporidiosis infection among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Olanzapine. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Olanzapine?

Olanzapine has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 69,242 Olanzapine users. Check the latest studies of Olanzapine.

On Jul, 18, 2026

94 people who take Vyvanse and Olanzapine together, and have interactions are studied.

Vyvanse and Olanzapine drug interactions.

What are the common drug interactions of Vyvanse and Olanzapine, by gender? *:

female:

Depressed mood
Disturbance in attention
Drug abuse
Drug dependence
Dysarthria (speech disorder)
Emotional disorder
Fatigue (feeling of tiredness)
Fumbling (the hands cold while doing or handling something)
Haemoglobin decreased
Hallucination, auditory (perceiving sounds without auditory stimulus)

male:

Cryptosporidiosis infection (an intestinal disease caused by the cryptosporidium parasite)
Diarrhoea
Abnormal loss of weight
Febrile neutropenia (fever with reduced white blood cells)
Fall
Burning sensation
Colitis ulcerative (inflammation of colon with ulcer)
Confusional state
Constipation
Craniocerebral injury (injury to cranium and brain)

What are the common drug interactions of Vyvanse and Olanzapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Erythema (redness of the skin)
Rash pruritic (redness with itching)
Urticaria (rash of round, red welts on the skin that itch intensely)

10-19:

Drug ineffective
Abdominal pain upper
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Fall
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Alanine aminotransferase increased

20-29:

Completed suicide (act of taking one's own life)
Adverse event
Device expulsion
Drug ineffective
Injection site reaction
Performance status decreased
Weight fluctuation
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite

30-39:

Cryptosporidiosis infection (an intestinal disease caused by the cryptosporidium parasite)
Diarrhoea
Pathogen resistance
Pyrexia (fever)
Weight decreased
Blood hiv rna increased
Anxiety
Drug abuse
Abdominal pain upper
Colitis ulcerative (inflammation of colon with ulcer)

40-49:

Weight increased
Aphasia (damage to the parts of the brain that control language)
Asthma
Chronic kidney disease
Dysarthria (speech disorder)
Fumbling (the hands cold while doing or handling something)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Overdose

50-59:

Muscle disorder (muscle disease)
Nerve injury
Physical assault
Psychomotor hyperactivity (feelings of extreme restlessness)
Somnambulism (sleep walking)
Speech disorder
Aggression
Chorea (abnormal involuntary movement disorder)
Choreoathetosis (involuntary movement randomly from one part to another body part)
Dysarthria (speech disorder)

60+:

Death
Heart rate increased

What are the existing conditions these people have? *

Hiv Infection: 28 people, 29.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 19.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 13.83%
Depression: 7 people, 7.45%
Stress And Anxiety: 5 people, 5.32%

* Approximation only. Some reports may have incomplete information.

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