Vyvanse and Xiidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Xiidra (lifitegrast). Common drug interactions include oesophageal candidiasis among females and dental care among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Xiidra. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Xiidra?

Xiidra has active ingredients of lifitegrast. eHealthMe is studying from 15,244 Xiidra users. Check the latest studies of Xiidra.

On Jul, 20, 2026

33 people who take Vyvanse and Xiidra together, and have interactions are studied.

What are the common drug interactions of Vyvanse and Xiidra, by gender? *:

female:

Oesophageal candidiasis (fungal infection of oesophagus)
Sinusitis (inflammation of sinus)
Alopecia (absence of hair from areas of the body)
Cataract (clouding of the lens inside the eye)
Connective tissue disorder (any disease that has the connective tissues of the body)
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Infusion site swelling
Lower respiratory tract infection
Retinal tear

male:

Dental care
Dry eye (lack of adequate tears)
Dysgeusia (disorder of the sense of taste)
Hypoacusis (loss of hearing)
Muscle spasms (muscle contraction)
Overweight
Diabetic nephropathy (diabetic kidney disease)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Type 2 diabetes mellitus
Blood cholesterol increased

What are the common drug interactions of Vyvanse and Xiidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dysgeusia (disorder of the sense of taste)

30-39:

Drug ineffective
Instillation site pain

40-49:

Ankle fracture
Fall
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Retinal degeneration (death of the cells of the retina)

50-59:

Type iii immune complex mediated reaction
Urinary tract infection
Arthropathy
Eye swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Abdominal pain upper
Bladder disorder

60+:

Alopecia (absence of hair from areas of the body)
Cataract (clouding of the lens inside the eye)
Skin infection
Soft tissue disorder (disease of soft tissue)
Type iii immune complex mediated reaction
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Renal disorder (kidney disease)
Suicidal ideation

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 36.36%
Immunodeficiency Common Variable: 11 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 18.18%
Dry Eyes (lack of adequate tears): 6 people, 18.18%
Primary Immunodeficiency Syndrome: 5 people, 15.15%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 12.12%
Urinary Hesitation (difficulty in beginning the flow of urine): 2 people, 6.06%
Cervical Spinal Stenosis (narrowing of the spinal canal in the neck): 2 people, 6.06%
Cystitis Interstitial (unknown cause characterized by bladder pain): 2 people, 6.06%
Drowsiness: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and Xiidra?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously