Wakix and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wakix (pitolisant hydrochloride) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include anxiety among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Wakix and Sudafed. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 18, 2026

16 people who take Wakix and Sudafed together, and have interactions are studied.

What are the common drug interactions of Wakix and Sudafed, by gender? *:

female:

Anxiety
Acne (skin problems that cause pimples)
Adverse drug reaction
Hunger
Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Paranasal sinus discomfort
Sleep-related eating disorder (abnormal eating patterns during the night)

male:

Blood pressure increased
Feeling drunk
Nerve compression
Peripheral swelling
Restless legs syndrome (a powerful urge to move your legs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Arthropathy
Full blood count decreased
Pain

What are the common drug interactions of Wakix and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acne (skin problems that cause pimples)
Adverse drug reaction
Anxiety
Hunger
Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Paranasal sinus discomfort
Sleep-related eating disorder (abnormal eating patterns during the night)

50-59:

n/a

60+:

Abnormal dreams
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Full blood count decreased
Pain
Pruritus (severe itching of the skin)
Sinus headache (headache caused by sinus infections)
Skin exfoliation (removal of the oldest dead skin cells)
Anaemia (lack of blood)
Blood chloride decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 93.75%
Drowsiness: 7 people, 43.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 43.75%

* Approximation only. Some reports may have incomplete information.

Do you take Wakix and Sudafed?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously