Amoxicillin and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amoxicillin (amoxicillin) and Naltrexone (naltrexone). Common drug interactions include diverticulitis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Amoxicillin and Naltrexone. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.



On Jul, 18, 2026

74 people who take Amoxicillin and Naltrexone together, and have interactions are studied.

Amoxicillin and Naltrexone drug interactions.

What are the common drug interactions of Amoxicillin and Naltrexone, by gender? *:

female:

  1. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  2. Drug abuse
  3. Dyspnoea (difficult or laboured respiration)
  4. Emotional distress
  5. Eye discharge
  6. Eye pain
  7. Eye pruritus (eye itching)
  8. Hip fracture
  9. Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  4. Hospitalisation
  5. Osteopenia (a condition where bone mineral density is lower than normal)
  6. Personality disorder
  7. Device dislocation
  8. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  9. Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
  10. Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)

What are the common drug interactions of Amoxicillin and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Device dislocation
  2. Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
  3. Weight gain poor

10-19:

  1. Abdominal distension
  2. Abdominal pain

20-29:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Influenza
  3. Injection site bruising
  4. Intervertebral disc protrusion (spinal disc protrusion)
  5. Road traffic accident
  6. Tendon rupture (tear of tendon)
  7. Wrist fracture
  8. Complication of device insertion

30-39:

  1. Bipolar disorder (mood disorder)
  2. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  3. Hospitalisation
  4. Insomnia (sleeplessness)
  5. Personality disorder
  6. Injection site erythema (redness at injection site)
  7. Injection site pruritus (severe itching at injection site)

40-49:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)
  4. Cellulitis (infection under the skin)
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Bone density decreased
  8. Emotional distress
  9. Fall
  10. Grip strength decreased

50-59:

  1. Chronic kidney disease
  2. Alopecia (absence of hair from areas of the body)
  3. Emotional distress
  4. Inflammation
  5. Neuropathy peripheral (surface nerve damage)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Blood pressure fluctuation
  9. Depression
  10. Lyme disease (a bacterial infection that is spread to humans by infected ticks)

60+:

  1. Alopecia (absence of hair from areas of the body)
  2. Fatigue (feeling of tiredness)
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. Insomnia (sleeplessness)
  5. Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
  6. Multiple fractures
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Neutropenia (an abnormally low number of neutrophils)
  9. Osteonecrosis (death of bone)
  10. Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 20.27%
  2. Pain: 13 people, 17.57%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 12.16%
  4. Immunodeficiency Common Variable: 7 people, 9.46%
  5. High Blood Cholesterol: 7 people, 9.46%
  6. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 8.11%
  7. High Blood Pressure: 6 people, 8.11%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.11%
  9. Insomnia (sleeplessness): 6 people, 8.11%
  10. Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Amoxicillin and Naltrexone:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amoxicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amoxicillin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naltrexone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin and naltrexone (the active ingredients of Amoxicillin and Naltrexone, respectively), and Amoxicillin and Naltrexone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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