Wellbutrin and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Odefsey. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Jul, 09, 2026

14 people who take Wellbutrin and Odefsey together, and have interactions are studied.

Wellbutrin and Odefsey drug interactions.

What are the common drug interactions of Wellbutrin and Odefsey, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Pain
Bone density decreased
Muscular weakness (muscle weakness)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Bone disorder
Protein urine present
Dysstasia (difficulty in standing)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Hypertension (high blood pressure)
Renal injury (kidney injury)
Asthenia (weakness)
Bone density decreased
Decreased activity
Dysstasia (difficulty in standing)
Impaired work ability
Insomnia (sleeplessness)

What are the common drug interactions of Wellbutrin and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Emotional distress
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pain

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Emotional distress
Pain
Protein urine present
Bone density decreased

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dysstasia (difficulty in standing)
Chronic kidney disease
Decreased activity
Impaired work ability
Insomnia (sleeplessness)
Oliguria (not enough urine)
Quality of life decreased
Renal impairment (severely reduced kidney function)
Skeletal injury (bone and supporting muscle injury)

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 28.57%
Osteoporosis (bones weak and more likely to break): 2 people, 14.29%
Diabetes: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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