Wellbutrin and Premphase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Premphase (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include rash among females.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Premphase. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

On Aug, 05, 2026

32 people who take Wellbutrin and Premphase together, and have interactions are studied.

Wellbutrin and Premphase drug interactions.

What are the common drug interactions of Wellbutrin and Premphase, by gender? *:

female:

Rash
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Oedema peripheral (superficial swelling)
Pain
Respiratory failure (inadequate gas exchange by the respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Cellulitis (infection under the skin)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug dependence

male:

n/a

What are the common drug interactions of Wellbutrin and Premphase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Suicidal ideation
Weight increased
Allergy to animal
Cough
Enuresis (repeated inability to control urination)
Faecal incontinence (a lack of control over passing stool)
House dust allergy
Inflammation
Lacrimation increased
Mood swings (an extreme or rapid change in mood)

50-59:

Anaemia (lack of blood)
Blood alkaline phosphatase increased
Cataract (clouding of the lens inside the eye)
Completed suicide (act of taking one's own life)
Decreased appetite
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Feeling cold
Glaucoma (increased fluid pressure in the eye with vision loss)
Gun shot wound

60+:

Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Red blood cell count decreased

What are the existing conditions these people have? *

Pain: 5 people, 15.62%
Shoulder Pain: 4 people, 12.50%
Sleep Disorder: 3 people, 9.38%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 9.38%
High Blood Pressure: 3 people, 9.38%
Upper Respiratory Tract Infection: 2 people, 6.25%
Stress And Anxiety: 2 people, 6.25%
Menstrual Disorder (disease of menstrual cycle): 2 people, 6.25%
Insomnia (sleeplessness): 2 people, 6.25%
Hot Flush (sudden feelings of heat): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and Premphase?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously