Wellbutrin and Propulsid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Propulsid (cisapride monohydrate). Common drug interactions include anhedonia among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Propulsid. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Propulsid?

Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.

On Jul, 11, 2026

78 people who take Wellbutrin and Propulsid together, and have interactions are studied.

Wellbutrin and Propulsid drug interactions.

What are the common drug interactions of Wellbutrin and Propulsid, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Pruritus (severe itching of the skin)
Swelling
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Angiopathy (generic term for a disease of the blood vessels)
Bacteraemia (presence of bacteria in the blood)
Bone disorder
Bone erosion
Bone fragmentation

male:

Weight increased
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Cardiac failure congestive
Constipation
Dissociative disorder
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Electrocardiogram abnormal
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrointestinal ulcer

What are the common drug interactions of Wellbutrin and Propulsid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Vomiting
Abdominal discomfort
Eating disorder
Nausea (feeling of having an urge to vomit)
Arrhythmia (irregular heartbeat)
Suicide attempt

20-29:

Dehydration (dryness resulting from the removal of water)
Asthenia (weakness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nausea (feeling of having an urge to vomit)
Therapeutic response decreased (less preventive response)
Urine analysis abnormal

30-39:

Arthralgia (joint pain)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Influenza like illness
Myalgia (muscle pain)
Oedema lower limb (fluid collection in tissue of lower leg)

40-49:

Mitral valve prolapse (heart's mitral valve doesn't work well)
Back pain
Cardiac failure congestive
Hypertension (high blood pressure)
Neck pain
Pain
Pruritus (severe itching of the skin)
Swelling
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Bone fragmentation
Congestive cardiomyopathy (weakening of heart muscle)
Cough
Deformity (disfigurement)
Dental fistula
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)
Emotional distress

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Asthenia (weakness)
Asthma
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose fluctuation
Cardiac failure congestive
Cardiolipin antibody positive

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 23 people, 29.49%
High Blood Pressure: 22 people, 28.21%
Fatigue (feeling of tiredness): 21 people, 26.92%
Impaired Gastric Emptying: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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