Xalkori and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xalkori (crizotinib) and Tylenol (acetaminophen). Common drug interactions include musculoskeletal stiffness among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Xalkori and Tylenol. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Xalkori?

Xalkori has active ingredients of crizotinib. eHealthMe is studying from 9,659 Xalkori users. Check the latest studies of Xalkori.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

On Aug, 08, 2026

92 people who take Xalkori and Tylenol together, and have interactions are studied.

What are the common drug interactions of Xalkori and Tylenol, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Skin tightness
Pneumonia
Malaise (a feeling of general discomfort or uneasiness)
Visual impairment
Decreased appetite
Fall
Neuropathy peripheral (surface nerve damage)
Non-small cell lung cancer metastatic (type of epithelial lung cancer spreads to other parts)
Lymphadenopathy (disease or enlargement of lymph nodes)

male:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Pneumonia
Cough
Disease progression
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Xalkori and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Back pain
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Local swelling (swelling at the site of some application of substance or injury)
Nausea (feeling of having an urge to vomit)
Neoplasm progression (growth of tumour)
Oedema peripheral (superficial swelling)
Vomiting

40-49:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting
Alanine aminotransferase increased
Asthenia (weakness)
Constipation
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Pulmonary embolism (blockage of the main artery of the lung)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Periorbital oedema (swelling around the eyes)
Photophobia (extreme sensitivity to light)
Sensation of foreign body
Visual impairment
Vomiting
Chest pain
Hepatic enzyme increased

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Dizziness
Hypotension (abnormally low blood pressure)
Decreased appetite
Vomiting
Influenza
Lower limb fracture
Bradycardia (abnormally slow heart action)
Constipation

What are the existing conditions these people have? *

Lung Neoplasm Malignant (cancer tumour of lung): 36 people, 39.13%
Lung Cancer - Non-Small Cell (lung cancer): 16 people, 17.39%
Nausea (feeling of having an urge to vomit): 15 people, 16.30%
Cough: 9 people, 9.78%
Wheezing (a high-pitched whistling sound made while you breath): 8 people, 8.70%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 7 people, 7.61%
Fever: 6 people, 6.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 5.43%
Dyspnea (difficult or laboured breathing): 5 people, 5.43%
Constipation: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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