Xanax and Depakene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xanax (alprazolam) and Depakene (valproic acid). Common drug interactions include atrioventricular block among females and drug abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Xanax and Depakene. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Xanax?

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 135,347 Xanax users. Check the latest studies of Xanax.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

On Jul, 10, 2026

97 people who take Xanax and Depakene together, and have interactions are studied.

What are the common drug interactions of Xanax and Depakene, by gender? *:

female:

Atrioventricular block (heart block)
Balance disorder
Blood lactate dehydrogenase increased
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cerebral atrophy (decrement in size of brain)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

male:

Drug abuse
Somnolence (a state of near-sleep, a strong desire for sleep)
Heart rate increased
Hyperthermia (body temperature greatly above normal)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Malaise (a feeling of general discomfort or uneasiness)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Neonatal disorder (disease of neonates)
Overdose
Sleep disorder

What are the common drug interactions of Xanax and Depakene, by age (0-1 to 60+)? *:

0-1:

Agitation neonatal (people with depression, obsessive-compulsive disorder, post viral fatigue syndrome, schizophrenia, bipolar i disorder)
Foetal arrhythmia (abnormal rate or rhythm of the foetus heartbeat)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Irritability
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Neonatal disorder (disease of neonates)
Premature baby
Sleep disorder
Tremor neonatal (excited neuromuscular activity of newborns)

2-9:

n/a

10-19:

n/a

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Multiple drug overdose intentional
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug exposure during pregnancy
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)

30-39:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug abuse
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Overdose
Abortion induced (medically referred abortion)
Asthenia (weakness)
Balance disorder
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)
Fall

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal abscess (collection of pus in abdomen)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Depressed level of consciousness
General physical health deterioration (weak health status)
Hemiparesis (weakness on one side of the body)
Hyperglycaemia (high blood sugar)

50-59:

Insomnia (sleeplessness)
International normalised ratio increased
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Micturition urgency (urgency to pass the urine)
Pain in extremity
Panic reaction
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Personality change
Photophobia (extreme sensitivity to light)

60+:

Thrombocytopenia (decrease of platelets in blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Transaminases increased
Tremor (trembling or shaking movements in one or more parts of your body)
Anticonvulsant drug level increased
Atrioventricular block (heart block)
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)

What are the existing conditions these people have? *

Suicide Attempt: 7 people, 7.22%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.15%
Bipolar Disorder (mood disorder): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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