Xarelto and Polymox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xarelto (rivaroxaban) and Polymox (amoxicillin). Common drug interactions include sinusitis among females.

The phase IV clinical study analyzes what interactions people have when they take Xarelto and Polymox. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,378 Xarelto users. Check the latest studies of Xarelto.

What is Polymox?

Polymox has active ingredients of amoxicillin. eHealthMe is studying from 78 Polymox users. Check the latest studies of Polymox.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

66 people who take Xarelto and Polymox together, and have interactions are studied.

What are the common drug interactions of Xarelto and Polymox, by gender? *:

female:

Sinusitis (inflammation of sinus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Embolism venous (embolus may pass into the arterial system)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Female genital tract fistula (passage in genital tract of female)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lower respiratory tract infection

male:

n/a

What are the common drug interactions of Xarelto and Polymox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Sinusitis (inflammation of sinus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Embolism venous (embolus may pass into the arterial system)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Female genital tract fistula (passage in genital tract of female)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lower respiratory tract infection

What are the existing conditions these people have? *

Seasonal Allergy (allergic condition due to certain season): 42 people, 63.64%

* Approximation only. Some reports may have incomplete information.

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