Xenazine and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xenazine (tetrabenazine) and Sinemet (carbidopa; levodopa). Common drug interactions include dyskinesia among females and ballismus among males.

The phase IV clinical study analyzes what interactions people have when they take Xenazine and Sinemet. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Xenazine?

Xenazine has active ingredients of tetrabenazine. eHealthMe is studying from 7,308 Xenazine users. Check the latest studies of Xenazine.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 15, 2026

25 people who take Xenazine and Sinemet together, and have interactions are studied.

What are the common drug interactions of Xenazine and Sinemet, by gender? *:

female:

Dyskinesia (abnormality or impairment of voluntary movement)
Death
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Depression
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Anxiety
Cough
Headache (pain in head)
Joint lock

male:

Ballismus (violent involuntary rapid and irregular movements)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Body temperature increased
Death
Fall
Pneumonia
Restlessness (not able to rest)
Skeletal injury (bone and supporting muscle injury)
Speech disorder

What are the common drug interactions of Xenazine and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)
Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)
Tremor (trembling or shaking movements in one or more parts of your body)
Reticulocyte count decreased

20-29:

n/a

30-39:

n/a

40-49:

Death
Nightmare (unpleasant dream)

50-59:

Dyskinesia (abnormality or impairment of voluntary movement)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Tardive dyskinesia (a disorder that involves involuntary movements)
Body temperature increased
Depression
Pneumonia
Suicidal ideation

60+:

Death
Anxiety
Weight decreased
Fall
Tardive dyskinesia (a disorder that involves involuntary movements)
Depressed mood
Hallucination (an experience involving the perception of something not present)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Abdominal pain lower
Anaemia (lack of blood)

What are the existing conditions these people have? *

Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 20.00%
Movement - Unpredictable Or Jerky: 3 people, 12.00%
Sleep Disorder: 2 people, 8.00%
Muscle Spasms (muscle contraction): 2 people, 8.00%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 2 people, 8.00%
Mitochondrial Myopathy (the muscle fibres do not function due to damage of mitochondria): 2 people, 8.00%
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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