Xenical and Sonata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xenical (orlistat) and Sonata (zaleplon). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Xenical and Sonata. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Xenical?

Xenical has active ingredients of orlistat. It is often used in weight loss. eHealthMe is studying from 11,722 Xenical users. Check the latest studies of Xenical.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

25 people who take Xenical and Sonata together, and have interactions are studied.

What are the common drug interactions of Xenical and Sonata, by gender? *:

female:

Drug ineffective
Eating disorder
Fatigue (feeling of tiredness)
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Impaired driving ability
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Muscle injury
Muscle spasms (muscle contraction)
Skeletal injury (bone and supporting muscle injury)

male:

Drug ineffective
Drug dependence
Visual disturbance
Vomiting
Abdominal hernia
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Depression
Diarrhoea
Dizziness

What are the common drug interactions of Xenical and Sonata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Oedema lower limb (fluid collection in tissue of lower leg)
Rectal bleeding (bleeding from rectum)
Steatorrhoea (presence of excess fat in faeces)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Oedema peripheral (superficial swelling)
Weight increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dependence
Drug abuse

50-59:

Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Speech disorder
Arrhythmia (irregular heartbeat)
Blood creatine phosphokinase mb
Blood creatine phosphokinase mb increased
Blood pressure increased
Cold sweat
Depressed level of consciousness

60+:

Drug ineffective
Drug dependence
Cardiac disorder
Diarrhoea
Dizziness
Headache (pain in head)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Pain: 18 people, 72.00%
Urinary Tract Infection: 5 people, 20.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 20.00%
Sinusitis (inflammation of sinus): 5 people, 20.00%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 20.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 20.00%
Mixed Incontinence (a combination of stress and urge incontinence): 5 people, 20.00%
Hypertriglyceridaemia (excess of triglycerides in the blood): 5 people, 20.00%
High Blood Pressure: 5 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Xenical and Sonata?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously