Hetlioz and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hetlioz (tasimelteon) and Nexium (esomeprazole magnesium). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Hetlioz and Nexium. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Hetlioz?

Hetlioz has active ingredients of tasimelteon. eHealthMe is studying from 7,418 Hetlioz users. Check the latest studies of Hetlioz.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

86 people who take Hetlioz and Nexium together, and have interactions are studied.

What are the common drug interactions of Hetlioz and Nexium, by gender? *:

female:

Drug ineffective
Insomnia (sleeplessness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Headache (pain in head)
Sleep disorder
Abnormal dreams
Diarrhoea
Initial insomnia (feeling of inadequate or poor-quality sleep)
Alopecia (absence of hair from areas of the body)

male:

Drug ineffective
Insomnia (sleeplessness)
Sleep disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Hospitalisation
Localised infection (infection at the single location)
Anticoagulation drug level below therapeutic
Asthenia (weakness)
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Hetlioz and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dizziness
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Abnormal dreams
Alopecia (absence of hair from areas of the body)
Limb discomfort (discomfort in leg)
Pain in extremity
Pregnancy

40-49:

Insomnia (sleeplessness)
Drug ineffective
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Sleep disorder
Abdominal discomfort
Adverse drug reaction
Depression
Headache (pain in head)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Blood pressure increased

50-59:

Drug ineffective
Somnolence (a state of near-sleep, a strong desire for sleep)
Hospitalisation
Localised infection (infection at the single location)
Anticoagulation drug level below therapeutic
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspepsia (indigestion)
Ear infection

60+:

Drug ineffective
Insomnia (sleeplessness)
Pneumonia
Somnolence (a state of near-sleep, a strong desire for sleep)
Syncope (loss of consciousness with an inability to maintain postural tone)
Unresponsive to stimuli
Headache (pain in head)
Fall
Memory impairment
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 32 people, 37.21%

* Approximation only. Some reports may have incomplete information.

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