Xgeva and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xgeva (denosumab) and Keppra (levetiracetam). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Xgeva and Keppra. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 06, 2026

100 people who take Xgeva and Keppra together, and have interactions are studied.

What are the common drug interactions of Xgeva and Keppra, by gender? *:

female:

Fatigue (feeling of tiredness)
Rash
Decreased appetite
Gastroduodenal haemorrhage (bleeding from stomach or duodenum ulcer)
Muscle spasms (muscle contraction)
Pain in extremity
Peripheral swelling
Severe acute respiratory syndrome (a serious form of pneumonia caused by virus infection)
Anaemia (lack of blood)
Asthenia (weakness)

male:

Fatigue (feeling of tiredness)
Death
Rash
Weight decreased
Bone pain
Acne (skin problems that cause pimples)
Anaemia (lack of blood)
Anxiety
Deafness
Dyspepsia (indigestion)

What are the common drug interactions of Xgeva and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Diarrhoea
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Renal failure (kidney dysfunction)

40-49:

Diarrhoea
Hypokalaemia (low potassium)
Soft tissue infection
Syncope (loss of consciousness with an inability to maintain postural tone)
Thrombocytopenia (decrease of platelets in blood)
Back pain
Leukopenia (less number of white blood cells in blood)
Severe acute respiratory syndrome (a serious form of pneumonia caused by virus infection)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Malignant neoplasm progression (cancer tumour came back)

50-59:

Malignant neoplasm progression (cancer tumour came back)
Adrenal disorder
Alopecia (absence of hair from areas of the body)
Anger
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Bacterial test positive
Cardiomegaly (increased size of heart than normal)
Constipation

60+:

Death
Decreased appetite
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Bone pain
C-reactive protein increased
Cardiac failure acute
Dementia (madness)
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 18 people, 18.00%
Prostate Cancer: 13 people, 13.00%
Multiple Myeloma (cancer of the plasma cells): 12 people, 12.00%
Pain: 8 people, 8.00%
Stress And Anxiety: 7 people, 7.00%
Lung Neoplasm Malignant (cancer tumour of lung): 6 people, 6.00%
Renal Cell Carcinoma (a kidney cancer): 5 people, 5.00%
Metastases To Bone (cancer spreads to bone): 5 people, 5.00%
High Blood Pressure: 5 people, 5.00%
High Blood Cholesterol: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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