Xifaxan and Versed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Versed (midazolam hydrochloride). Common drug interactions include clavicle fracture among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Versed. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Versed?

Versed has active ingredients of midazolam hydrochloride. It is often used in sedation during medical procedure. eHealthMe is studying from 6,869 Versed users. Check the latest studies of Versed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

17 people who take Xifaxan and Versed together, and have interactions are studied.

What are the common drug interactions of Xifaxan and Versed, by gender? *:

female:

Clavicle fracture
Cough
Erythema (redness of the skin)
Memory impairment
Osteoporosis (bones weak and more likely to break)
Suicidal ideation
Surgery
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Weight increased
Depression

male:

Anxiety
Chronic kidney disease
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspepsia (indigestion)
Fear
Gastric cancer (stomach cancer)

What are the common drug interactions of Xifaxan and Versed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Chronic kidney disease
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mobility decreased (ability to move is reduced)
Pain
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

50-59:

Hepatic failure (liver failure)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Gastric cancer (stomach cancer)
Injury
Metastases to peritoneum (cancer spreads to peritoneum)
Metastatic gastric cancer (cancer types can spread to the stomach from other place)
Multi-organ failure (multisystem organ failure)
Normal pressure hydrocephalus (a neurological disorder in which there is too much cerebrospinal fluid in the ventricles of the brain)
Pain
Pancreatic carcinoma (pancreatic cancer)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 35.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 35.29%
High Blood Pressure: 4 people, 23.53%
Pain: 4 people, 23.53%
Infection: 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
Hepatitis B: 3 people, 17.65%
Hiv Infection: 3 people, 17.65%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 11.76%
Indigestion: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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