Xigris and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xigris (drotrecogin alfa (activated)) and Digoxin (digoxin). Common drug interactions include catheter site haemorrhage among females and brain herniation among males.

The phase IV clinical study analyzes what interactions people have when they take Xigris and Digoxin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Xigris?

Xigris has active ingredients of drotrecogin alfa (activated). eHealthMe is studying from 3,542 Xigris users. Check the latest studies of Xigris.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

On Jul, 25, 2026

26 people who take Xigris and Digoxin together, and have interactions are studied.

What are the common drug interactions of Xigris and Digoxin, by gender? *:

female:

Catheter site haemorrhage (bleeding at catheter site)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Escherichia infection (bacterial infection by escherichia coli)
Platelet count decreased
Proteus infection (proteus can cause urinary tract infections)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Thrombocytopenia (decrease of platelets in blood)
Vaginal haemorrhage (vaginal bleeding)
Alanine aminotransferase increased
Arterial haemorrhage

male:

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Blood bilirubin increased
Blood creatinine increased
Cardiac arrest
Cardiovascular disorder (heart diseases)
Circulatory collapse
Colonic polyp (extra part of colon tissue grow in intestine)
Congestive cardiomyopathy (weakening of heart muscle)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the common drug interactions of Xigris and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Catheter site haemorrhage (bleeding at catheter site)
Vaginal haemorrhage (vaginal bleeding)
Arterial haemorrhage
Blood pressure decreased
Heart rate decreased
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Platelet count decreased

40-49:

n/a

50-59:

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Escherichia infection (bacterial infection by escherichia coli)
Intraventricular haemorrhage (intraventricular bleeding)
Proteus infection (proteus can cause urinary tract infections)
Pyrexia (fever)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Thrombocytopenia (decrease of platelets in blood)
Acute respiratory distress syndrome
Ascites (accumulation of fluid in the abdominal cavity)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
General physical health deterioration (weak health status)
Haemoglobin decreased
Hepatic failure (liver failure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypoxia (low oxygen in tissues)
International normalised ratio increased
Lactic acidosis (low ph in body tissues)
Multiple injuries

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 10 people, 38.46%
Septic Shock (shock due to blood infection): 6 people, 23.08%
Sedation: 2 people, 7.69%
Neuromuscular Blockade: 2 people, 7.69%
Hyperglycemia (high blood sugar): 2 people, 7.69%
Cardiac Disorder: 2 people, 7.69%
Arrhythmias (irregular heartbeat): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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