1. Home
  2. Analysis
  3. Xopenex
  4. Trulance

Xopenex and Trulance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xopenex (levalbuterol hydrochloride) and Trulance (plecanatide). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Xopenex and Trulance. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Xopenex?

Xopenex has active ingredients of levalbuterol hydrochloride. It is often used in asthma. eHealthMe is studying from 13,816 Xopenex users. Check the latest studies of Xopenex.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

On Jul, 19, 2026

14 people who take Xopenex and Trulance together, and have interactions are studied.

Xopenex and Trulance drug interactions.

What are the common drug interactions of Xopenex and Trulance, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Impaired gastric emptying
  3. Pain
  4. Pneumonia
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Abdominal adhesions (inflammation of abdomen)
  7. Abdominal discomfort
  8. Anxiety
  9. Asthma exercise induced
  10. Back pain

male:

n/a

What are the common drug interactions of Xopenex and Trulance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints)

50-59:

  1. Anxiety
  2. Back pain
  3. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  4. Infusion site erythema (reddening of the skin at infusion site)
  5. Infusion site rash
  6. Lower respiratory tract infection
  7. Mycobacterium avium complex infection
  8. Nausea (feeling of having an urge to vomit)
  9. Nephrolithiasis (calculi in the kidneys)
  10. Obstruction

60+:

n/a

What are the existing conditions these people have? *

  1. Drowsiness: 8 people, 57.14%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 35.71%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 35.71%
  4. Sleep Disorder: 4 people, 28.57%
  5. Urinary Tract Infection: 1 person, 7.14%
  6. Sinusitis (inflammation of sinus): 1 person, 7.14%
  7. Seasonal Allergy (allergic condition due to certain season): 1 person, 7.14%
  8. Irritable Bowel Syndrome: 1 person, 7.14%
  9. Immunodeficiency Common Variable: 1 person, 7.14%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Xopenex and Trulance?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Xopenex and Trulance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xopenex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Trulance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xopenex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trulance and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on levalbuterol hydrochloride and plecanatide (the active ingredients of Xopenex and Trulance, respectively), and Xopenex and Trulance (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.