Xtandi and Mitoxantrone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xtandi (enzalutamide) and Mitoxantrone (mitoxantrone hydrochloride). Common drug interactions include malignant neoplasm progression among males.

The phase IV clinical study analyzes what interactions people have when they take Xtandi and Mitoxantrone. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Xtandi?

Xtandi has active ingredients of enzalutamide. eHealthMe is studying from 51,498 Xtandi users. Check the latest studies of Xtandi.

What is Mitoxantrone?

Mitoxantrone has active ingredients of mitoxantrone hydrochloride. eHealthMe is studying from 8,125 Mitoxantrone users. Check the latest studies of Mitoxantrone.



On Jul, 28, 2026

19 people who take Xtandi and Mitoxantrone together, and have interactions are studied.

Xtandi and Mitoxantrone drug interactions.

What are the common drug interactions of Xtandi and Mitoxantrone, by gender? *:

female:

n/a

male:

  1. Malignant neoplasm progression (cancer tumour came back)
  2. Disease progression
  3. Prostatic specific antigen increased
  4. Vomiting
  5. Ascites (accumulation of fluid in the abdominal cavity)
  6. Metastases to liver (cancer spreads to liver)
  7. Neoplasm progression (growth of tumour)
  8. Osteonecrosis of jaw (death of bone of jaw)
  9. Nausea (feeling of having an urge to vomit)
  10. Free prostate-specific antigen positive

What are the common drug interactions of Xtandi and Mitoxantrone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pneumonia

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  3. Body temperature increased
  4. Constipation
  5. Death
  6. Drug ineffective
  7. Prostatic specific antigen increased
  8. Vomiting
  9. Neoplasm progression (growth of tumour)
  10. Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

  1. Prostate Cancer: 6 people, 31.58%

* Approximation only. Some reports may have incomplete information.

Do you take Xtandi and Mitoxantrone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Xtandi and Mitoxantrone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xtandi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Mitoxantrone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xtandi and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mitoxantrone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on enzalutamide and mitoxantrone hydrochloride (the active ingredients of Xtandi and Mitoxantrone, respectively), and Xtandi and Mitoxantrone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: