Xtandi and Prozac drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Xtandi (enzalutamide) and Prozac (fluoxetine hydrochloride). Common drug interactions include affect lability among females and fatigue among males.
The phase IV clinical study analyzes what interactions people have when they take Xtandi and Prozac. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.
What is Xtandi?
Xtandi has active ingredients of enzalutamide. eHealthMe is studying from 51,498 Xtandi users. Check the latest studies of Xtandi.
What is Prozac?
Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.
57 people who take Xtandi and Prozac together, and have interactions are studied.

What are the common drug interactions of Xtandi and Prozac, by gender? *:
female:
- Affect lability (emotional incontinence)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Diarrhoea
- Nightmare (unpleasant dream)
male:
- Fatigue (feeling of tiredness)
- Asthenia (weakness)
- Lethargy (tiredness)
- Malignant neoplasm progression (cancer tumour came back)
- Blood pressure increased
- Colitis ulcerative (inflammation of colon with ulcer)
- Fall
- Haemorrhage (bleeding)
- Peripheral swelling
- Pruritus generalised (generalized itching)
What are the common drug interactions of Xtandi and Prozac, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Malignant neoplasm progression (cancer tumour came back)
- Sepsis (a severe blood infection that can lead to organ failure and death)
60+:
- Fatigue (feeling of tiredness)
- Diarrhoea
- Haemorrhage (bleeding)
- Pruritus generalised (generalized itching)
- Rhinorrhoea (watery mucus discharge from the nose)
- Hot flush (sudden feelings of heat)
- Erythema (redness of the skin)
- Fall
- Disturbance in attention
- Gastrointestinal disorder (functional problems of gastrointestinal tract)
What are the existing conditions these people have? *
- Prostate Cancer: 35 people, 61.40%
- Prostate Cancer Metastatic: 6 people, 10.53%
- High Blood Pressure: 3 people, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Xtandi and Prozac?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Xtandi and Prozac:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Xtandi:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Prozac:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Xtandi and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Prozac and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on enzalutamide and fluoxetine hydrochloride (the active ingredients of Xtandi and Prozac, respectively), and Xtandi and Prozac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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