Xylocaine and Depo-medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xylocaine (lidocaine hydrochloride) and Depo-medrol (methylprednisolone acetate). Common drug interactions include injury among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Xylocaine and Depo-medrol. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Xylocaine?

Xylocaine has active ingredients of lidocaine hydrochloride. eHealthMe is studying from 5,716 Xylocaine users. Check the latest studies of Xylocaine.

What is Depo-medrol?

Depo-medrol has active ingredients of methylprednisolone acetate. It is often used in birth control. eHealthMe is studying from 5,933 Depo-medrol users. Check the latest studies of Depo-medrol.

On Jul, 19, 2026

95 people who take Xylocaine and Depo-medrol together, and have interactions are studied.

Xylocaine and Depo-medrol drug interactions.

What are the common drug interactions of Xylocaine and Depo-Medrol, by gender? *:

female:

Injury
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Gait disturbance
Bacterial infection
Burning sensation
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)
Skin discolouration (change of skin colour)
Vomiting

male:

Pain
Arthralgia (joint pain)
Nausea (feeling of having an urge to vomit)
Streptococcal infection
Abdominal hernia
Asthenia (weakness)
Back pain
Blood glucose increased
Chest pain
Chondrolysis (a condition that occurs when there is sudden, severe damage to joint cartilage)

What are the common drug interactions of Xylocaine and Depo-Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dry skin
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Osteomyelitis (infection of bone)
Pain
Rash erythematous (redness of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rash pruritic (redness with itching)
Skin atrophy (wasting of skin)

30-39:

Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urticaria (rash of round, red welts on the skin that itch intensely)
Visual disturbance
Weakness

40-49:

Pain
Vomiting
Weight increased
Ear disorder
Fluid retention (an abnormal accumulation of fluid in the blood)
Gingival bleeding (bleeding gums)
Impaired healing
Injection site pain
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Myopathy steroid (a muscular disease in which the muscle fibres do not function due to steroid)

50-59:

Constipation
Gastric ulcer (stomach ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Injury
Intestinal obstruction
Irritable bowel syndrome
Melanosis coli (a condition that can be caused from chronic laxative abuse)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Fall

60+:

Muscular weakness (muscle weakness)
Dysphagia (a condition in which swallowing is difficult or painful)
Anxiety
General physical health deterioration (weak health status)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Burning sensation
Hypoaesthesia (reduced sense of touch or sensation)
Muscle twitching
Sensory loss (senses loss)
Bacterial infection

What are the existing conditions these people have? *

Pain: 21 people, 22.11%
Joint Pain: 17 people, 17.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.42%
Back Pain: 7 people, 7.37%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 6 people, 6.32%
Nerve Block (the interruption of signals travelling along a nerve): 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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