Xyrem and D-ribose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and D-ribose (ribose). Common drug interactions include chills among females and middle insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and D-ribose. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is D-ribose?

D-ribose has active ingredients of ribose. eHealthMe is studying from 109 D-ribose users. Check the latest studies of D-ribose.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

42 people who take Xyrem and D-ribose together, and have interactions are studied.

What are the common drug interactions of Xyrem and D-Ribose, by gender? *:

female:

Chills (felling of cold)
Disturbance in attention
Drug administration error
Feeling of body temperature change
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tongue disorder (disease of tongue)
Tremor (trembling or shaking movements in one or more parts of your body)
Upper respiratory tract infection
Alopecia (absence of hair from areas of the body)
Anxiety

male:

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Poor quality sleep
Hypertension (high blood pressure)

What are the common drug interactions of Xyrem and D-Ribose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypertension (high blood pressure)

30-39:

Decreased appetite
Discomfort
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

40-49:

Concussion (short loss of normal brain function in response to a head injury)
Headache (pain in head)
Migraine (headache)
Nephrolithiasis (calculi in the kidneys)
Drug ineffective
Dry mouth
Hypertension (high blood pressure)
Visual impairment
Anaphylactic reaction (serious allergic reaction)
Blood pressure increased

50-59:

Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Poor quality sleep
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Insomnia (sleeplessness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Sedation
Back pain
Intervertebral disc protrusion (spinal disc protrusion)

60+:

Bradycardia (abnormally slow heart action)
Viral infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 21.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 14.29%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 6 people, 14.29%
Rosacea (a skin condition that causes facial redness): 3 people, 7.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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