Xyrem and Epitol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Epitol (carbamazepine). Common drug interactions include lipoma among females and eczema among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Epitol. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Epitol?

Epitol has active ingredients of carbamazepine. It is often used in bipolar disorder. eHealthMe is studying from 397 Epitol users. Check the latest studies of Epitol.

On Jul, 09, 2026

24 people who take Xyrem and Epitol together, and have interactions are studied.

What are the common drug interactions of Xyrem and Epitol, by gender? *:

female:

Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Retinal tear
Arthralgia (joint pain)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Headache (pain in head)
Influenza like illness
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Adjustment disorder with depressed mood

male:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pain
Sinus disorder (disease of sinus)

What are the common drug interactions of Xyrem and Epitol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Influenza like illness
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Adjustment disorder with depressed mood
Calculus bladder (bladder stone)
Cystitis interstitial (unknown cause characterized by bladder pain)
Urticaria (rash of round, red welts on the skin that itch intensely)
Drug ineffective
Euphoric mood (excessively happy but may become angry or irritable)
Feeling drunk

50-59:

Death
Surgery

60+:

n/a

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 45.83%
Pain: 3 people, 12.50%
Hypersensitivity: 3 people, 12.50%
Asthma: 3 people, 12.50%
Neuromyelitis Optica (inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis)): 2 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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