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Xyrem and Eplerenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Eplerenone (eplerenone). Common drug interactions include death among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Eplerenone. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

On Jun, 17, 2026

21 people who take Xyrem and Eplerenone together, and have interactions are studied.

Xyrem and Eplerenone drug interactions.

What are the common drug interactions of Xyrem and Eplerenone, by gender? *:

female:

  1. Death
  2. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  3. Disease progression
  4. Oedema peripheral (superficial swelling)
  5. Reaction to drug excipients
  6. Renal failure (kidney dysfunction)

male:

  1. Weight decreased
  2. Dyspnoea (difficult or laboured respiration)
  3. Lung disorder (lung disease)
  4. Neck injury
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Claustrophobia (fear of having no escape and being closed in small spaces)
  7. Drug ineffective
  8. Gout (uric acid crystals building up in the body)
  9. Insomnia (sleeplessness)
  10. Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)

What are the common drug interactions of Xyrem and Eplerenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Weight decreased
  2. Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
  3. Drug hypersensitivity
  4. Hypoacusis (loss of hearing)
  5. Retching (strong involuntary effort to vomit)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Tachyphylaxis (a medical term describing an acute (sudden) decrease in the response to a drug after its administration)
  8. Disease progression
  9. Oedema peripheral (superficial swelling)
  10. Reaction to drug excipients

60+:

  1. Death

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 71.43%
  2. Drowsiness: 6 people, 28.57%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and Eplerenone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Xyrem and Eplerenone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xyrem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Eplerenone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xyrem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Eplerenone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate and eplerenone (the active ingredients of Xyrem and Eplerenone, respectively), and Xyrem and Eplerenone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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