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Xyrem and Fml forte drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Fml forte (fluorometholone). Common drug interactions include incisional drainage among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Fml forte. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Fml forte?

Fml forte has active ingredients of fluorometholone. eHealthMe is studying from 168 Fml forte users. Check the latest studies of Fml forte.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

22 people who take Xyrem and Fml forte together, and have interactions are studied.

Xyrem and Fml forte drug interactions.

What are the common drug interactions of Xyrem and Fml Forte, by gender? *:

female:

  1. Incisional drainage
  2. Joint swelling
  3. Exposure to toxic agent
  4. Bladder dysfunction
  5. Blood pressure increased
  6. Diarrhoea
  7. Disability
  8. Gastritis (inflammation of stomach)
  9. Lagophthalmos (the inability to close the eyelids completely)
  10. Nasal disorder (diseases of nose)

male:

  1. Sinusitis (inflammation of sinus)
  2. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the common drug interactions of Xyrem and Fml Forte, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  2. Arthroscopic surgery
  3. Exposure to toxic agent
  4. Bladder dysfunction
  5. Diarrhoea
  6. Gastritis (inflammation of stomach)
  7. Lagophthalmos (the inability to close the eyelids completely)
  8. Oesophagitis (inflammation of oesophagus)
  9. Pruritus (severe itching of the skin)
  10. Oesophageal spasm (contraction of oesophagus)

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 81.82%
  2. Drowsiness: 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and Fml forte?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Xyrem and Fml forte:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xyrem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fml forte:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xyrem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fml forte and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate and fluorometholone (the active ingredients of Xyrem and Fml forte, respectively), and Xyrem and Fml forte (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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