Xyrem and Librax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyrem (sodium oxybate) and Librax (chlordiazepoxide hydrochloride; clidinium bromide). Common drug interactions include fibromyalgia among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Xyrem and Librax. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Librax?

Librax has active ingredients of chlordiazepoxide hydrochloride; clidinium bromide. eHealthMe is studying from 660 Librax users. Check the latest studies of Librax.

On Jul, 28, 2026

30 people who take Xyrem and Librax together, and have interactions are studied.

What are the common drug interactions of Xyrem and Librax, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Muscle spasms (muscle contraction)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Memory impairment
Migraine (headache)
Depression
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Neuropathy peripheral (surface nerve damage)
Head injury
Drug ineffective

male:

Drug ineffective
Insomnia (sleeplessness)
Cough
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Irritable bowel syndrome
Restless legs syndrome (a powerful urge to move your legs)
Peripheral swelling
Abdominal pain upper
Diarrhoea
Surgery

What are the common drug interactions of Xyrem and Librax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Pain
Stress
Suicidal ideation

40-49:

Abdominal pain upper
Anxiety
Cough
Decreased appetite
Depression
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Head injury
Increased appetite
Memory impairment
Migraine (headache)

50-59:

Drug ineffective
Insomnia (sleeplessness)
Blood pressure increased
Bruxism (habitual grinding of the teeth, typically during sleep)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Sleep talking (talking during sleeping)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug intolerance (drug sensitivity)
Fall

60+:

Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Eye disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Intervertebral disc disorder (spinal disc disorder)
Nerve compression
Neuropathy peripheral (surface nerve damage)
Abdominal discomfort
Diarrhoea
Surgery

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 36.67%
Drowsiness: 8 people, 26.67%
Muscle Spasms (muscle contraction): 4 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.67%
Stress And Anxiety: 2 people, 6.67%
Pain: 2 people, 6.67%
Migraine (headache): 2 people, 6.67%
High Blood Pressure: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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