Macrobid and Xyzal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Xyzal (levocetirizine dihydrochloride). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Xyzal. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

On Jul, 19, 2026

26 people who take Macrobid and Xyzal together, and have interactions are studied.

What are the common drug interactions of Macrobid and Xyzal, by gender? *:

female:

Fatigue (feeling of tiredness)
Anxiety
Breath holding
Constipation
Disturbance in attention
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Eye haemorrhage (bleeding in the eye)
Headache (pain in head)
Hypersensitivity

male:

n/a

What are the common drug interactions of Macrobid and Xyzal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Restless legs syndrome (a powerful urge to move your legs)
Tachyphrenia (abnormally rapid mental activity)
Victim of spousal abuse
Weight decreased
Anxiety
Therapeutic response unexpected
Coma (state of unconsciousness lasting more than six hours)
Decreased appetite

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dependence
Drug abuse
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eating disorder
Fall

50-59:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Abdominal distension
Abdominal hernia
Abdominal pain
Alanine aminotransferase increased
Angioedema (rapid swelling of the dermis)
Aspartate aminotransferase increased
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

60+:

Abdominal pain
Blood pressure increased
Jaundice acholuric (elevated unconjugated bilirubin that is not excreted by the kidney)
Localised infection (infection at the single location)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Precancerous skin lesion
Pruritus generalised (generalized itching)
Rash
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 53.85%
High Blood Pressure: 11 people, 42.31%
Hypersensitivity: 10 people, 38.46%
Stress And Anxiety: 9 people, 34.62%
Thrombosis (formation of a blood clot inside a blood vessel): 8 people, 30.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 30.77%
Ill-Defined Disorder: 7 people, 26.92%
Constipation: 6 people, 23.08%
Pain: 4 people, 15.38%
Insomnia (sleeplessness): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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