Flexeril and Common peroneal nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Common peroneal nerve dysfunction is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Ambien, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Common peroneal nerve dysfunction when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Common peroneal nerve dysfunction?

Common peroneal nerve dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes) is found to be associated with 651 drugs and 1,129 conditions by eHealthMe. Check the latest studies of Common peroneal nerve dysfunction.

On Jul, 19, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 76 people (0.22%) have Common peroneal nerve dysfunction.

Could Flexeril cause Common peroneal nerve dysfunction?

Among these 76 people:

How long have people been on Flexeril when they have Common peroneal nerve dysfunction? *

What is the gender of people who have Common peroneal nerve dysfunction when taking Flexeril? *

female: 69.74 %
male: 30.26 %

What is the age of people who have Common peroneal nerve dysfunction when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides Common peroneal nerve dysfunction? *

Weakness: 44 people, 57.89%
Intervertebral Disc Protrusion (spinal disc protrusion): 40 people, 52.63%
Fall: 39 people, 51.32%
Osteomyelitis (infection of bone): 38 people, 50.00%
Pain In Extremity: 35 people, 46.05%
Joint Pain: 33 people, 43.42%
Gait Disturbance: 33 people, 43.42%
Hypoaesthesia (reduced sense of touch or sensation): 29 people, 38.16%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 29 people, 38.16%
Stress And Anxiety: 27 people, 35.53%

What are the existing conditions these people have? *

Stress And Anxiety: 18 people, 23.68%
Multiple Myeloma (cancer of the plasma cells): 17 people, 22.37%
Pain: 14 people, 18.42%
Insomnia (sleeplessness): 14 people, 18.42%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 14.47%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 14.47%
Metastases To Bone (cancer spreads to bone): 10 people, 13.16%
Back Disorder: 6 people, 7.89%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 6.58%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Common peroneal nerve dysfunction?

- Check whether Common peroneal nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,308 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Common peroneal nerve dysfunction:

Common peroneal nerve dysfunction (651 drugs)

Browse all the conditions that are associated with Common peroneal nerve dysfunction:

Common peroneal nerve dysfunction (1,129 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.