Xyzal and Xifaxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyzal (levocetirizine dihydrochloride) and Xifaxan (rifaximin). Common drug interactions include dizziness among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Xyzal and Xifaxan. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

On May, 15, 2026

34 people who take Xyzal and Xifaxan together, and have interactions are studied.

What are the common drug interactions of Xyzal and Xifaxan, by gender? *:

female:

Dizziness
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Rectal abscess (pus in rectum)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain upper

male:

Hospitalisation
Pruritus (severe itching of the skin)
Scab (a hard coating on the skin formed during the wound healing)

What are the common drug interactions of Xyzal and Xifaxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pruritus (severe itching of the skin)
Scab (a hard coating on the skin formed during the wound healing)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Breast cancer
Abdominal pain upper
Blood immunoglobulin g decreased
Blood immunoglobulin m decreased
Cd4 lymphocytes decreased
Constipation
Diarrhoea
Disease recurrence
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Anorectal disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Coeliac disease (simple food intolerance)
Dehydration (dryness resulting from the removal of water)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Drug administration error
Drug effect decreased
Ear haemorrhage (bleeding from ear)

What are the existing conditions these people have? *

Sleep Disorder: 12 people, 35.29%
Hereditary Angioedema (recurrent episodes of severe swelling): 6 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 11.76%
Hypersensitivity: 3 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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