Yasmin and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Yasmin (drospirenone; ethinyl estradiol) and Melatonin (melatonin). Common drug interactions include pulmonary embolism among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Yasmin and Melatonin. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Yasmin?

Yasmin has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 48,855 Yasmin users. Check the latest studies of Yasmin.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

72 people who take Yasmin and Melatonin together, and have interactions are studied.

What are the common drug interactions of Yasmin and Melatonin, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Anxiety
Cholecystitis chronic (long lasting infection of gallbladder)
Emotional distress
Depression
Gallbladder disorder
Nausea (feeling of having an urge to vomit)
Pain in extremity
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain

male:

Headache (pain in head)
Hypertension (high blood pressure)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Nausea (feeling of having an urge to vomit)
Pain
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Yasmin and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Oropharyngeal pain
Throat irritation
Cholecystitis chronic (long lasting infection of gallbladder)
Injury
Pain
Affective disorder (mental disorder)
Anxiety
Haematochezia (passage of stools containing blood)
Hospitalisation
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)

20-29:

Nausea (feeling of having an urge to vomit)
Pain
Abdominal pain
Injury
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Anxiety
Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

30-39:

Pain
Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Heart rate increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Sphincter of oddi dysfunction (dysfunction of a muscular valve that controls the flow of digestive juices)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)

40-49:

Oedema peripheral (superficial swelling)
Pleural effusion (water on the lungs)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pleuritic pain
Carotid artery dissection
Carotid artery stenosis (narrowing of carotid artery)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Deformity (disfigurement)
Embolic stroke (stroke due to obstruction due to an embolus)
Headache (pain in head)

50-59:

Pain
Emotional distress
Pulmonary embolism (blockage of the main artery of the lung)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Pulmonary infarction (death of a small area of lung)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Balance disorder

60+:

Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Speech disorder
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Stress
Surgery
Depression

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 13 people, 18.06%
Premenstrual Syndrome: 12 people, 16.67%
Pain: 11 people, 15.28%
Sleep Disorder: 10 people, 13.89%
Nausea (feeling of having an urge to vomit): 9 people, 12.50%
Stress And Anxiety: 7 people, 9.72%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 6 people, 8.33%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 6.94%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 6.94%
Diabetes: 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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