Yondelis and Decadron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Yondelis (trabectedin) and Decadron (dexamethasone). Common drug interactions include blood creatine phosphokinase increased among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Yondelis and Decadron. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Yondelis?

Yondelis has active ingredients of trabectedin. eHealthMe is studying from 1,220 Yondelis users. Check the latest studies of Yondelis.

What is Decadron?

Decadron has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 47,210 Decadron users. Check the latest studies of Decadron.

On Jul, 12, 2026

17 people who take Yondelis and Decadron together, and have interactions are studied.

Yondelis and Decadron drug interactions.

What are the common drug interactions of Yondelis and Decadron, by gender? *:

female:

Blood creatine phosphokinase increased
Neutropenia (an abnormally low number of neutrophils)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Asthenia (weakness)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Sputum increased
Abdominal discomfort
Acute respiratory distress syndrome
Alanine aminotransferase increased

male:

Platelet count decreased
Blood bilirubin increased
Duodenal ulcer
Gamma-glutamyltransferase increased
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Nausea (feeling of having an urge to vomit)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Capillary leak syndrome (capillary leaks plasma)
Cardiac failure

What are the common drug interactions of Yondelis and Decadron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Neutropenia (an abnormally low number of neutrophils)
Blood creatine phosphokinase increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Capillary leak syndrome (capillary leaks plasma)
Cardiac failure
Febrile neutropenia (fever with reduced white blood cells)
Full blood count decreased
Pyrexia (fever)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sputum increased
Asthenia (weakness)
Gastrointestinal toxicity (damage to digestive tract by any substance)
Haematotoxicity (toxins that destroy red blood cells)
Urinary tract infection

60+:

Platelet count decreased
Blood bilirubin increased
Gamma-glutamyltransferase increased
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Nausea (feeling of having an urge to vomit)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Diarrhoea

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 3 people, 17.65%
Liposarcoma (a cancer tumour that arises in fat cells in deep soft tissue): 3 people, 17.65%
Leiomyosarcoma Metastatic (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue spreading to other parts): 3 people, 17.65%
Leiomyosarcoma (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue): 2 people, 11.76%
Synovial Sarcoma Metastatic (tumour of synovial membrane of joint spreads to other): 2 people, 11.76%
Renal Impairment (severely reduced kidney function): 2 people, 11.76%
Pain: 2 people, 11.76%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 2 people, 11.76%
High Blood Pressure: 2 people, 11.76%
Uterine Leiomyosarcoma (uterus cancer of smooth muscle connective tissue): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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