Zithromax and Norflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zithromax (azithromycin) and Norflex (orphenadrine citrate). Common drug interactions include dyspnoea among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Zithromax and Norflex. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Zithromax?

Zithromax has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 35,525 Zithromax users. Check the latest studies of Zithromax.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

On Jul, 12, 2026

19 people who take Zithromax and Norflex together, and have interactions are studied.

Zithromax and Norflex drug interactions.

What are the common drug interactions of Zithromax and Norflex, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bipolar disorder (mood disorder)
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Chills (felling of cold)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug addiction

male:

Headache (pain in head)
Chest pain
Vertigo
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal tenderness
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Balance disorder
Benign prostatic hyperplasia (benign enlargement of the prostate)

What are the common drug interactions of Zithromax and Norflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bipolar disorder (mood disorder)
Blood pressure increased
Chills (felling of cold)
Chronic kidney disease
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression

40-49:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug ineffective
Pruritus (severe itching of the skin)

50-59:

Blood creatinine increased
Headache (pain in head)
Influenza like illness
Myopathy (a muscular disease in which the muscle fibres do not function)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)
Sweating increased (excess sweating)
Vomiting

60+:

Blood cholesterol increased
Blood triglycerides increased
Nausea (feeling of having an urge to vomit)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Depression
Drug hypersensitivity
Emotional distress
Hypertension (high blood pressure)
Fall

What are the existing conditions these people have? *

Pain: 2 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Respiratory Disorder (respiratory disease): 1 person, 5.26%
Renal Disorder (kidney disease): 1 person, 5.26%
Premenstrual Syndrome: 1 person, 5.26%
Indigestion: 1 person, 5.26%
Headache (pain in head): 1 person, 5.26%
Gastric Disorder (disease of stomach): 1 person, 5.26%
Cough: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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