Zaleplon and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zaleplon (zaleplon) and Azelastine (azelastine hydrochloride). Common drug interactions include herpes simplex among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zaleplon and Azelastine. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Zaleplon?

Zaleplon has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 1,935 Zaleplon users. Check the latest studies of Zaleplon.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

On Aug, 11, 2026

36 people who take Zaleplon and Azelastine together, and have interactions are studied.

Zaleplon and Azelastine drug interactions.

What are the common drug interactions of Zaleplon and Azelastine, by gender? *:

female:

Herpes simplex (herpes simplex is a common viral infection)
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Immune system disorder
Infection
Influenza
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)

male:

Pain
Anxiety
Eye irritation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic enzyme increased
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypokalaemia (low potassium)
Obesity (having too much body fat)
Oropharyngeal pain

What are the common drug interactions of Zaleplon and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Agitation (state of anxiety or nervous excitement)
Diarrhoea
Micturition urgency (urgency to pass the urine)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Restlessness (not able to rest)

50-59:

Asthenia (weakness)
Death
Eyelid ptosis (falling of the upper or lower eyelid)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Neuropathy peripheral (surface nerve damage)
Pain
Pancreatic carcinoma (pancreatic cancer)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Peripheral nerve injury

60+:

Dizziness
Abdominal discomfort
Oedema peripheral (superficial swelling)
Pneumonia
Sinusitis (inflammation of sinus)
Application site pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 47.22%
Drowsiness: 4 people, 11.11%
Pain: 3 people, 8.33%
Immunodeficiency Common Variable: 3 people, 8.33%
High Blood Pressure: 3 people, 8.33%
Multiple Allergies (allergy to multiple agents): 2 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.56%
Asthma: 2 people, 5.56%
Amyotrophic Lateral Sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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