Zantac 150 and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zantac 150 (ranitidine hydrochloride) and Prograf (tacrolimus). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zantac 150 and Prograf. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Zantac 150?

Zantac 150 has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 6,519 Zantac 150 users. Check the latest studies of Zantac 150.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 16, 2026

44 people who take Zantac 150 and Prograf together, and have interactions are studied.

Zantac 150 and Prograf drug interactions.

What are the common drug interactions of Zantac 150 and Prograf, by gender? *:

female:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Blood creatinine increased
Blood pressure decreased
Blood pressure increased
Blood urea increased
Bone marrow failure
Culture urine positive
Escherichia infection (bacterial infection by escherichia coli)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

male:

Chronic kidney disease
Blood albumin decreased
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Diarrhoea
Infection
Pyrexia (fever)
Drug hypersensitivity
Pseudarthrosis (bones that do not heal after fracture)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Zantac 150 and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Vomiting
Blood pressure decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary oedema (fluid accumulation in the lungs)
Acute respiratory distress syndrome
Epistaxis (bleed from the nose)
Haematemesis (vomiting of blood)
Nausea (feeling of having an urge to vomit)
Pulmonary haemorrhage (acute bleeding from the lung)

10-19:

Apnoea (suspension of external breathing)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Headache (pain in head)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Carotid artery stenosis (narrowing of carotid artery)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemorrhage intracranial (bleeding within the skull)
Heart transplant rejection
Blood creatinine increased

20-29:

Kidney transplant rejection

30-39:

Blood albumin decreased
Blood lactate dehydrogenase increased
Pneumonia
Osteomyelitis (infection of bone)
Sternal fracture
Transplant rejection (a transplant material is not worked)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Pyrexia (fever)
Drug hypersensitivity
Pseudarthrosis (bones that do not heal after fracture)

40-49:

Renal haematoma (blood collection in kidney)
Urinary retention (the inability to completely or partially empty the bladder)

50-59:

Arthralgia (joint pain)
Haematocrit decreased
Kidney transplant rejection
Myalgia (muscle pain)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Renal graft loss

60+:

Chronic kidney disease
Infection
Intestinal obstruction
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pleural effusion (water on the lungs)
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 9.09%
High Blood Cholesterol: 4 people, 9.09%
Diabetes: 4 people, 9.09%
Renal Disorder (kidney disease): 3 people, 6.82%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 3 people, 6.82%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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